MendelianMR

Browser-based Mendelian Randomization analysis tool.

Methods

• IVW (fixed + random effects) — primary estimate
• MR-Egger — directional pleiotropy detection via intercept test
• Weighted Median — robust when ≥50% weight from valid instruments
• Simple Median — robust when ≥50% instruments valid
• MR-PRESSO — outlier detection with global test + Bonferroni correction

Diagnostics

• Cochran's Q, I² heterogeneity
• F-statistics for instrument strength
• Leave-one-out sensitivity analysis

Plots

• Scatter (SNP-exposure vs SNP-outcome with method lines)
• Forest (individual Wald ratios + summary diamonds)
• Funnel (asymmetry detection)
• Leave-one-out

Example Datasets

• LDL → CHD (28 SNPs)
• BMI → T2DM (14 SNPs)
• SBP → Stroke (8 SNPs)
• CRP → CHD (5 SNPs, pleiotropy example)

Live Demo

https://mahmood726-cyber.github.io/MendelianMR/

Author

Mahmood Ahmad, Tahir Heart Institute