跨队列分析MASLD不同严重阶段及MASLD相关肝细胞癌中的脂质代谢和Hippo–YAP转录程序。Cross-cohort transcriptomic analysis of lipid metabolism and Hippo–YAP programs across MASLD severity and MASLD-associated hepatocellular carcinoma.

Production-grade multimodal deep learning for biological imaging and spatial transcriptomics, with reproducible data ingestion, image quality control, segmentation, phenotype classification, uncertainty estimation, and transcriptomic interpretation.

Computational analysis of single-nucleus ATAC-seq data to identify cell-type-specific MASLD-associated regulatory peaks not captured by liver eQTLs and link them to candidate genes using ABC, developed for HUJI’s Computational Genomics course (76553)

About the speliotes lab

A clinical-grade biophysical simulation of Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) and Cirrhosis. Built with Spring Boot, Next.js, and Three.js, it translates FIB-4 laboratory parameters into real-time WebGL organ deformations and ECG electrophysiology models.

OWL is a biotechnology company that uses metabolomics to develop early diagnosis products for highly prevalent diseases. The first disease targeted was fatty liver disease (non-alcoholic fatty liver disease and non-alcoholic fatty liver disease)

Liver Lipidomics Paper

Analyze biological imaging and spatial transcriptomics data using robust deep learning pipelines and verified dataset auditing.

Reproducible code and public-safe Source Data for measurement-aware serial liver elastography trajectories in MASLD.