Phenotypic screening of a CRISPRi strain library [Smith et 2017, Mol Syst Biol (2017)13:913] for acetic acid tolerance targeting essential and respiratory essential genes in Saccharomyces cerevisiae
🌱 Designing CRISPRi experiments in bacteria
Repository containing the code and methods for Bosch & DeJesus et al. 2021
PyTorch classifier predicting CRISPRi guide identity from single-cell expression (Adamson et al. 2016 Perturb-seq)
Adversarial-debate LLM agent for predicting CRISPRi perturbation effects on gene expression (Genentech MLGenX BioReasoning Challenge)
Reproducible CRISPRi/Perturb-seq analysis of an ENTPD1/CD39 T-cell program in rheumatoid arthritis and methotrexate treatment
Computational design and adversarial validation of synthetic gene circuits targeting PDAC transcription factors, trained from scratch on real public genomics data
AI-assisted platform for designing CRISPR experiments — from target selection to bench-ready protocols
Figure code and data for Johnson et al. 2021, J Am Chem Soc 143(31):12003-12013, doi:10.1021/jacs.1c02622. CRISPRi chemical genomics identifying IleRS as the target of thiomarinol
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